IL-22 and IL-17: An Overview
نویسندگان
چکیده
Many studies from recent years have shown that cytokines like IL-22, IL-17A, and IL-17F play a major role in both the defense against certain microbes and the development and maintenance of chronic inflammatory diseases. These mediators are often secreted by subpopulations of T-helper cells called Th17 cells and Th22 cells, respectively. This chapter provides an overview about the common and differing properties of IL-22, IL-17A, and IL-17F with respect to their genes, protein structure, cellular sources, receptors, target cells, and biological effects. Surprisingly, with the exception of a few similarities, most basic aspects of IL-22 and IL-17A/IL-17F are different.
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